# AI pathology → androgen deprivation duration

Source: https://onco.cc/pairings/ai-pathology-to-adt/  
OnCo record `ai-pathology-to-adt` (Pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

An AI reading of the biopsy slide says whether adding hormone therapy to radiation will help.

## Summary

This diagnostic-therapeutic pairing links Digital pathology & AI to the choice of Androgen deprivation & AR pathway inhibitors in Prostate cancer: an AI reading of the biopsy slide says whether adding hormone therapy to radiation will help. The rationale is that tissue morphology encodes biology beyond the Gleason grade, and because the model was trained on randomised trial cohorts its prediction is causal for treatment effect. ArteraAI Prostate, authorised by the FDA through the de novo pathway in 2025, predicts benefit from short-term androgen deprivation in intermediate-risk disease using slides from RTOG trials, and it is listed by the NCCN. The pairing is reached from the Prostate cancer, Digital pathology & AI and Androgen deprivation entries.

## Fields

- Kind: Pairing
- Last checked: 2026-09-04
- Pairs: Digital pathology & AI + Androgen deprivation & AR pathway inhibitors
- Type: diagnostic-therapeutic
- Rationale: Morphology encodes biology beyond Gleason grade; trained on randomised trial cohorts so the prediction is causal for treatment effect.
- Evidence: Validated on phase 3 cohorts; FDA-authorised.

## Sources

- Esteva et al., Prostate cancer therapy personalisation via multimodal deep learning on randomised phase 3 trials (npj Digital Medicine 2022): https://doi.org/10.1038/s41746-022-00613-w

## Connected records

- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- drugs: [ArteraAI Prostate](https://onco.cc/drugs/artera-ai-prostate/)
- key papers: [Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials](https://onco.cc/key-papers/paper-esteva-npj-digit-med/)
- technologies: [Androgen deprivation & AR pathway inhibitors](https://onco.cc/technologies/androgen-deprivation/), [Digital pathology & AI](https://onco.cc/technologies/digital-pathology-ai/)

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